Th1 dominant leprosy
Tubercoid leprosy Low levels of organism, low infectivity Granulomas and local inflammation Normal serum Ig levels Normal T cell responsiveness, response to leprae infection
Th2 dominant leprosy
Lepromatous leprosy
Large amount of organism growth, high infectivity
Disseminated infection
Hypergammaglobulinemia
Low/absent T cell responsiveness, no response to infection