Lymphoma

Question 1

what is a lymphoma?

Answer 1

clonal proliferation of lymphocytes arising in a lymph node or associated tissue
• a SOLID TUMOUR but some cells in blood

Question 2

what are the types of lymphoma?

Answer 2

1. hodgkin lymphoma

2. non-hodgkin lymphoma

Question 3

what lymphoma is more common?

Answer 3

non-hodgkin lymphoma (6:1)

Question 4

what are some symptoms of lymphoma?

Answer 4

• fever
• swelling of face & neck
• lump in neck, armpit, groin
• excessive night sweats
• unexpected weight loss
• loss of appetite
• breathlessness
• itchiness
• weakness

Question 5

what age is peak incidence for hodgkin lymphoma?

Answer 5

15-40 years

Question 6

are males or females more likely to get hodgkin lymphoma?

Answer 6

males

Question 7

what are the clinical presentations of hodgkin lymphoma?

Answer 7

• painless lymphadenopathy
• fever, night sweats, weight loss & itching
• infection

Question 8

what is the cure prognosis for stages 1 and 2 of hodgkin lymphoma?

Answer 8

> 90%

Question 9

what is the cure prognosis for stages 3 and 4 hodgkin lymphoma?

Answer 9

50-70%

Question 10

what are the kinds of non-hodgkin lymphoma?

Answer 10

B cell related or T cell related

Question 11

what is more common, B cell lymphoma or T cell lymphoma?

Answer 11

B cell (85%)
T cell (15%)

Question 12

what is the aetiology of nonhodgkin lymphoma?

Answer 12

• microbial factors
• autoimmune disease
• immunosuppression

Question 13

what are some microbial factors that can trigger non-hodgkin lymphoma?

Answer 13

• HIV

* EBV etc. can trigger malignancy

Question 14

autoimmune diseases involved in the aetiology of non-hodgkin lymphoma

Answer 14

Sjögren’s syndrome, rheumatoid arthritis, peptic ulcer disease

Question 15

how does non-hodgkin lymphoma present itself?

Answer 15

• lymphadenopathy
• extra-nodal disease
• symptoms of marrow failure

Question 16

what is meant by multiple myeloma?

Answer 16

malignant proliferation of plasma cells