1
Q
Superficial spreading melanoma
- which parts of the body? male vs. female?
- name the two growth phases
- histologic distribution of melanocytes
- which layer?
A
- most common melanoma
- sun-exposed skin; backs of men and lower legs of women
- radial growth, vertical growth
- buckshot scatter (pagetoid spread)
- epidermis
2
Q
Lentigo maligna/lentigo malign melanoma (-indolent, slow growing melanoma)
- where is it typically found?
- which growth phase is dominant?
- how can you tell that the lesion has become malignant?
- distinguishing cytologic features:
A
- typically found on the face of elderly
- long radial growth phase (10-50 years)
- when it’s palpable, which signals dermal invasion and vertical growth
- poorly nested and confluent melanocytes and d-e-jxn, adnexal extension, sun damage!
3
Q
acral lentiginous melanoma (least common melanoma)
- most common race
- location
A
- most common in african americans and asians
- palms, soles, beneath the nail plate *Hutchinson’s sign
4
Q
nodular melanoma
- location
- layer and growth phase
- key histologic feature
A
- anywhere
- dermis, no apparent radial growth phase, grows rapidly in the vertical direction
- atypical mitoses everywhere
