May 17

Question 1

what mutation causes Job syhndrome?

Answer 1

STAT3

Question 2

path of job syndrome?

Answer 2

STAT3 mutation leads to Th17 cell deficiency and decreased IFNgamma production by t cells -> impaired neutrophil chemotaxis

Question 3

presentation of Job syndrome

Answer 3

-abscesses, recurrent sinopulmonary infections, eczema, coarse facial features, primary teeth retention, orthopedic probelms