MCTD

Question 1

what defines MCTD

Answer 1

2 of the any of the following: SLE, DM/PM, scleroderma, or RA

Question 2

what is the targeted autoAB

Answer 2

anti-U1RNP

Question 3

what is the HLA a/w

Answer 3

HLA-DR4

Question 4

tx

Answer 4

prednisone + MTX if severe arthritis (must use with caution in MCTD patients given risk of pulmonary fibrosis)

Question 5

how many of these patients will develop into 6 distinct CTD

Answer 5

40%

Question 6

what is the ANA nuclear pattern?

Answer 6

speckled