MDS

Question 1

Mimic of MDS boards likes to test

Answer 1

copper deficiency

Question 2

Diseases associated with psuedo-pelger huet cells

Answer 2

CML, AML, MDS

Question 3

Good risk cytogenetic findings in MDS

Answer 3

*-Y
- del5q
- del11q
- del12p
- del20q

Question 4

Poor risk cytogenetic findings in MDS

Answer 4

• complex karyotype
• del7
• inversions or deletions of chromosome 3

Question 5

How to think of risk stratification of mutations in MDS

Answer 5

• SF3b1 is good risk, everything else is bad risk

Question 6

Treatment of choice for MDS w/ 5q-

Answer 6

lenalidomide

Question 7

hypoplastic MDS managment

Answer 7

treated similar to aplastic anemia with triple IST

Question 8

contraindication to use of iron chelators

Answer 8

CrCL<40

Question 9

MDS bone marrow findings

Answer 9

• hyperproliferative
• cellular dysplasia

Question 10

Demographics - gender + ethnicity at higher risk

Answer 10

Men at higher risk
White people at higher risk
*think MDS patient

Question 11

Other MDS RF’s

Answer 11

• radioactive iodine

Question 12

hypoplastic MDS management

Answer 12

immunosuppression (treated similarly to aplastic anemia)
- cyclosporine + ATG

Question 13

Mutation with most favorable prognosis in MDS

Answer 13

SF3B1

Question 14

Disease associated with SRSF2

Answer 14

CMML