Med Biochem Flashcards by Michael Nel

Q

How does tissue damage occur in diabetes

A

consistently elevated plasma glucose leads to glucose oxidation and linkage of glucose to plasma proteins
results in altered protein function

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Q

Why do diabetics get dehydrated?

A

high glucose levels in plasma exceeds renal threshold
glucose not reabsorbed from renal tubules and appears in urine
glucose in tubules increases osmotic pressure of the filtrate, increasing the amount if water associated with the urine
increased urine excretion

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Q

Origin of high glucose levels in plasma of diabetics

A

plasma glucose not taken up by tissues because glut 4 not activated
liver stimulated to activate gluconeogenesis

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