Medication Profiles

Question 1

What class of drug is carboplatin?

Answer 1

Alkylating agents

Question 2

What is the contraindication for carboplatin?

Answer 2

Known hypersensitivity

Question 3

What class is cyclophosphamide?

Answer 3

AA

Question 4

What is the formula for GFR?

Answer 4

N = 1.04 (females) and 1.23 (males)

GFR = N x (140-Age) x Weight (in kg)
___________________________
Serum creatinine

Question 5

What class is cisplatin?

Answer 5

• AA

- Platinum compound type

Question 6

What is a contradiction for cisplatin?

Answer 6

• Severe renal impairment (nephrotoxic)
• Myelosuppresion
• Hearing impaired (ototoxic)

Question 7

What class is doxorubicin?

Answer 7

Anthracycline antibiotic

Question 8

What is the contraindication for doxorubicin?

Answer 8

• Hypersensitivity
• Lifetime max dose **
• Severe hepatic impairment
• Cardiac issues (cardiotoxic)

Question 9

What class does rituximab belong to?

Answer 9

Monoclonal antibodies

Question 10

What is the contraindication for rituximab?

Answer 10

Previous hypersensitivity

Question 11

What are the precautions for rituximab?

Answer 11

• 1st time reactions ** decreased with subsequent infusions
• TLS (with increased tumor burden)
• age >65, greater risk of cardiac/pulm toxicities

Question 12

What drug class is paclitaxel?

Answer 12

Plant alkaloid, antimicrotuble agent

Question 13

What is the contraindication for paclitaxel?

Answer 13

• Pre-existing liver impairment
• Elderly
• AIDS
• Caution: no live vaccines

Question 14

What class does vincristine belong to?

Answer 14

Vinka alkaloids

Question 15

What is the contraindication for vincristine?

Answer 15

• Neuropathies

- Liver failure

Question 16

What class does oxaliplatin belong to?

Answer 16

AA

Question 17

What are contraindications for oxaliplatin?

Answer 17

• hypersensitivities to platinums (carbo, cis)
• peripheral neuropathies
• CKD (<30 GFR)
• Cardiac hx (prolonged QT) (use with caution)

Question 18

What class does fluorouracil belong to?

Answer 18

Antimetabolites

Question 19

What are the contraindications for fluorouracil?

Answer 19

Hypersensitive reactions to it or capectibine

Question 20

What class does etoposide belong to?

Answer 20

• Vinca alkaloids, topo inhibitor

- cycle specific to S and G2 phase

Question 21

What class does irinotecan belong to?

Answer 21

• Plant alkaloids, topo inhibitors

- S phase specific

Question 22

What are the main adverse effects of aklylating agents as a group?

Answer 22

Myelosuppresion
Sterility
N/V
Diarrhea
Neuropathies - peripheral and central (oto and oculuar)
Alopecia
TLS and SIADH
Renal toxicity - electrolyte disturbance

Question 23

What are the main adverse effects of anti-tumor ABX as a group?

Answer 23

Myelosuppresion
Cardiotoxic
TLS

Question 24

What group of drugs causes renal toxicity?

Answer 24

AA’s

Question 25

What groups of drugs cause liver toxicity?

Answer 25

AA's and vinca alkaloids

Question 26

What group of drugs causes neurotoxicities?

Answer 26

AA's | Includes peripheral and central (eyes, ears)

Question 27

What drugs cause cardiac toxicity?

Answer 27

``` Paclitaxel Rituximab Oxaliplatin Doxorubicin Fluorouracil ``` Fussy ducks observed raccoons playing

Question 28

What is the main adverse effects of anti-metabolites?

Answer 28

Myelosuppression Skin/derm changes - PPE and mucositis Diarrhea

Question 29

What is the main adverse effects of MAb's?

Answer 29

``` Hypersensitive reactions TLS (12-24 hours post) Myelosuppresion Nausea Fever/chills Rash ```

Question 30

What is the main adverse effects of vinca alkaloids?

Answer 30

``` Myelosuppresion N/v Mucositis Muscle aches / cholinergic responses ECG changes Neuropathies TLS and SIADH Alopecia Constipation (sometimes diarrhea, irinotecan and etoposide) ```

Question 31

What is the key side effect of doxorubicin?

Answer 31

``` Red pee 1-2 days GI symptoms (n/v and diarrhea, sore mouth) (think of how ABX trash the GI usually) Pigmentation changes ```

Question 32

What is the key side effect of cyclophosphamide?

Answer 32

Cystitis | Drink ++ water and pee frequently

Question 33

What is the key side effect of cisplatin?

Answer 33

``` Multiple toxicities (renal, neurological) (Encourage to drink + water for renal) ```

Question 34

What is the key side effect of paclitaxel?

Answer 34

Hypersensitivity reactions | Fever and myalgia's first 24 hours

Question 35

What is the key side effect of oxaliplatin?

Answer 35

Cold dysthesias

Question 36

What is the key side effect of rituximab?

Answer 36

Hypersensitive reactions ** | Fever and chills 24x hours after tx

Question 37

What is the key side effect of fluororacil?

Answer 37

PPE, cardiotoxic | Have seen ASAP if any heart changes

Question 38

What is the key side effect of etoposide?

Answer 38

++ GI issues (diarrhea or const) Sore mouth Alopecia

Question 39

What is the key side effect of irinotecan?

Answer 39

Diarrhea | No radiation at the same time!

Question 40

What is a key side effect of carboplatin?

Answer 40

Ocular and ototoxicity | Assess for signs

Question 41

What drugs from the guide manual cause alopecia?

Answer 41

Doxorubicin Paclitaxel Etoposide