Meds

Question 1

What medications are inducers of the P450 system?

Answer 1

Rifampicin
St John's Wort
AntiE: Carbamezepine, Phenytoin
Chronic OH-
Griseofulvin
Smoking
Barbituates

Question 2

What medications are inhibitors of the P450 system?

Answer 2

Abx: Erythromycin, Ciprofloxacin
Amiodarone
Allopurinol
Cimetidine, Omeprazole
Na Valproate
Imidazoles: Ketoconazole, Fluconazole
Acute OH- intake
SSRI: Fluoxetine, Sertraline

Question 3

What are the specific SE of the different antibiotics?

Answer 3

Amoxicillin= Rash w/EBV
Co-Amox= Cholestasis
Metronidazole= OH- reaction
Ciprofloxacin= Tendonitis, lowers seizure threshold
Flucloxacin= Cholestasis
Doxycycline= Photosensitivity
Trimethoprim= Rash, pruritus, photosensitivity, suppresses haematopoesis
Erythromycin= GI, prolonged QT

Question 4

What are the SE of the anti-hypertensive groups?

Answer 4

ACEi= Cough, hyperK
BB= BronchoS, fatigue, cold peripheries
CCB= Headache, flushing, ankle oedema
Verapamil= HF, Constipation, Brady, HypoT, Flushing
Diltiazem= HypoT, Brady, Acute oedema 
Nif/Aml/Fle= Flushing, acute oedema 
Bendro= Gout, hypoN, hypoK, impaired glucose
Doxazosin= Postural hypoT

Question 5

What are the SE of the diabetic med groups?

Answer 5

Met= GI, lactic acidosis
Sulfonylureas= Liver dysfunction, SIADH, HypoG, ↑appetite & weight
Glitazones= HypoG, Liver dysfunction, #, ↑weight, fluid retention

Question 6

How does LMWH work?

Answer 6

Activates antithrombin III

Question 7

How does unfractionated Heparin work?

Answer 7

Inhibits thrombin, factor IXa, Xa, XIa, XIIa

Question 8

What is a common SE of both LMWH & UF Heparin?

Answer 8

HyperK

Inhibit aldosterone secretion

Question 9

What is Heparin induced thrombocytopenia?

Answer 9

Day 5-10 of Tx
Immune mediated antibodies
Complexes induce platelet activation
Tx= alternative anticoagulant

Question 10

What drugs can cause pulmonary fibrosis?

Answer 10

Methotrexate
Chemo
Amiodarone
Abx: Nitrofurantoin