1
Q
What causes megaloblastic anemia?
A
Deficiency of folate and B12( cobalamin)
2
Q
What is defective in this anemia?
A
DNA synthesis is impaired so all cells are affected giving pancytopenia
3
Q
What is seen in morphology?
A
1) megaloblasts
2) hypersegmented neutrophils FIRST SIGN
3) hyper cellular bone marrow
egg shaped macro-ovalocytes
Anemias Of Decrease Erythropoiesis
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