Melanoma cell of origin?
Melanocytes
De novo or ∆ in existing mole
Risk factors for Melanoma?
UV exposure
Genetic
Superficial Spreading Melanoma presentation?
Most C
U male backs, female legs
Growth horizontal vs vertical
Nodular Melanoma presentation?
Rapid vertical growth
Breslow’s Depth is?
measurement of lesion thickness from epi granular layer to deepest art of tumor
Lentigo Melanoma presentation?
Chronic UV exposure areas
Slow horizontal growth
Acral Lentiginous Melanoma presentation?
U darker-skinned pts
Amelanotic Melanoma presentation?
Variable morph, subtle or no pigment
ABCDE of Melanoma?
A = asymm (unmatching sides) B = irreg borders C = multi or unusual colors D = diameter > pencil eraser E = evolving/changing
Most important factor for survival?
thickness/depth of invasion