Menopause

Question 1

MOA

Answer 1

Decreased estrogen production due to age-linked decline in number of ovarian follicle

Question 2

Onset

Answer 2

At 51 years, earlier in smokers

Question 3

Preceding symptoms

Answer 3

4-5 years of abn menstrual cycles.

Question 4

Source of estrogen after menopause

Answer 4

Source of estrogen (estrone) after menopause becomes peripheral conversion of androgens.

Increased androgens causes hirsutism

Question 5

Best confirmation

Answer 5

Increased FSH:

due to loss of freeback for FSH due to low estrogen.

Question 6

Hormonal changes

Answer 6

Low estrogen
HIGH HIGH FSH
high LH (no surge)
high GnRH

Question 7

Symptoms

Answer 7

HHAVOC:
Hirsutism,
Hot flashes,
Atropy of Vagina
Osteoporosis
Coronary artery disease

Question 8

If before 40 yrs of age

Answer 8

Premature ovarian failure.