Meta-Analysis

Question 1

What is meta-analysis?

Answer 1

Optional part of systematic review that calculates a treatment effect based on pooled data from a group of studies

Question 2

What are the key features of meta-analysis?

Answer 2

• pooling data
• statistical methods used to weight results of individual studies to reduce bias
• heterogeneity assessment
• publication bias analysis
• generalisation of conclusions

Question 3

What is heterogeneity?

Answer 3

The variability in outcomes due to differences in study designs, populations, interventions or methodologies

Question 4

What are the types of heterogeneity?

Answer 4

• statistical
• methodological
• clinical