MG/LEMS

Question 1

3ish Associated Disorders w/ MG

Answer 1

Thymoma/hyperplastic thymus
Hyper/hypothyroidism
Other AI disorders

Question 2

Tensilon Test

Answer 2

Edrophonium test for MG, use short acting AChE inhibitor and see if it works

Question 3

3+ Treatments for MG

Answer 3

Anti-AChEs, then steroids, then immunosuppressive drugs, then more severe

Question 4

LEMS as Warning SIgn

Answer 4

Often Precedes cancer

Question 5

2 Autonomic Signs of LEMS

Answer 5

Dry mouth, impotence in men

Question 6

Big Pathophys Difference b/w MG and LEMS

Answer 6

MG defect is postsynaptic, LEMS is presynaptic at active zones

Question 7

Treatment for LEMS

Answer 7

3,4-Diaminopyridine blocks outward K+ current, prolonging duration of presynaptic AP