1
Q
BacteriCIDAL
A
Beta Lactams Monopenem Carbapenem Vancomycin Quinolones Aminoglycosides Metronidazole
2
Q
Bacteristatic
A
Sulfanamides Tetracycline Trimethoprim Chloramphenicol Lincosamides: Clindamycin Linezolid Macrolides: Erythromycin Spectinomycin
3
Q
Microbial Defenses
A
Pump out ab
Destroy ab
Compete for binding site
4
Q
Inhibitors of Cell wall synthesis
A
PCN Cephalosporins Vancomycin Bacitracin Isoniazid Ethambutol Echinocandins (anti-fungal)
5
Q
Beta Lactams mechanism of action
A
Beta Lactams compete with binding site for cross linking of peptide b/t NAG and NAM. PBP.
6
Q
Penicillin
A
Good renal clearance.
Stays in most tissues at therapeutic levels well.
Not in CSF
Not effective against intracellular organisms
Mechanism: Beta Lactam ring
7
Q
Beta Lactam Imposters (Decoy)
A
Clavulanic acid
Sulbactam
Tazobactam
8
Q
Probenecid
A
Inducer of renal reduction allowing more PCN to stay in circulation
9
Q
Cephalosporins
A
Similar to PCN
Enters CSF
10
Q
Monobactams
A
Narrow spectrum
Gram -
Pseudomonas and Enterobacter
PCAP
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