What is a mutation?
change in genetic information (nucleotide sequence) of an organism’s DNA
How do mutations arise?
errors during DNA replication/recombination
errors introduced when repairing DNA damage
errors induced by environmental or chemical mutagens
What are the types of mutations
small scale
substitution - when a single
nucleotide is replaced by another
silent mutation and
replacement mutation
Insertion/deletion - when one or more nucleotide are added or removed
Large scale
mutations in chromosomal
structure like translocations,
inversions, duplications,
chromosomal loss.