Microscopic Polyangitis

Question 1

What is microscopic polyangiitis?

Answer 1

A small-vessel ANCA-associated vasculitis.

Question 2

What renal features occur in microscopic polyangiitis?

Answer 2

Renal impairment with raised creatinine, haematuria, and proteinuria.

Question 3

What systemic symptoms may be seen in microscopic polyangiitis?

Answer 3

Fever, lethargy, myalgia, and weight loss.

Question 4

What skin and neurological features can occur in microscopic polyangiitis?

Answer 4

Skin: palpable purpura. Neurological: mononeuritis multiplex.

Question 5

What respiratory symptoms occur in microscopic polyangiitis?

Answer 5

Cough, dyspnoea, and haemoptysis.

Question 6

What ANCA patterns are associated with microscopic polyangiitis?

Answer 6

pANCA (MPO): positive in 50–75% cANCA (PR3): positive in 40%.