Midazolam

Question 1

What is the drug classification of Midazolam?

Answer 1

Benzodiazepine

Question 2

What is the action of Midazolam?

Answer 2

CNS depressant that enhances the action of the inhibitory neurotransmitter gamma-amino butyric acid (GABA) - this results in sedation, amnesia, hypnosis and anaesthesia

Question 3

What schedule is Midazolam classified under?

Answer 3

Schedule 4 (Restricted Drugs)

Question 4

What are the side effects of Midazolam?

Answer 4

• Hypertension

- Respiratory depression especially when associated with other CNS depressants including alcohol and narcotics

Question 5

What are the indications for administering Midazolam?

Answer 5

Generalized seizures/ focal seizures (GCS < 12)

Question 6

What are the contraindications for Midazolam?

Answer 6

Known severe allergic reaction

Question 7

What are the precautions to consider when administering Midazolam?

Answer 7

• Can cause severe respiratory depression in patients with COPD
• Elderly, chronic renal failure, congestive heart failure and shock (use reduced dose)
• Respiratory tract burns

Question 8

When should the dosage be reduced?

Answer 8

• Elderly patients
• Patients with chronic renal failure
• Patients with congestive heart failure
• Patients suffering from shock

Question 9

What is the onset time for IM administration?

Answer 9

5 - 15 minutes

Question 10

What is the onset time for IV administration?

Answer 10

1 - 3 minutes

Question 11

What is the onset time for NAS administration?

Answer 11

1 - 3 minutes