What are the Choline esters
Acetylcholine
Metacholine (Mecholyl)
Carbachol
Bethanechol (Urecholine)
Quaternary ammonium that cannot penetrate
membranes
Acetylcholine
Resistant to enzymatic hydrolysis than Acetylcholine
Metacholine (Mecholyl)
Very potent ester (both muscarinic and
nicotinic)
Carbachol
not hydrolyzed by cholinesterase
Bethanechol (Urecholine)
Uses of Bethanechol (Urecholine)
Gastric retention
Postoperative abdominal distention
Nonobstructive urinary retention
Paralytic ileus