Mirabegron

Question 1

Alternate Name

Answer 1

Myrbetriq

Question 2

Description

Answer 2

Synthetic selective Beta3 receptor agonist (with much less activity at Beta1 and Beta2 receptors)

Question 3

Actions

Answer 3

Stimulation of B3 receptors in Smooth Muscle of bladder -> reduces detrusor muscle tone

Question 4

Indications

Answer 4

1. Treatment of patients with overactive bladder with features of urinary urgency or frequency
2. Increases bladder capacity
3. Does not produce bothersome anticholinergic symptoms like tolteridine

Question 5

Other facts

Answer 5

1. FDA approved 2012

2. Administered orally as extended release tablets