0
Q
What % children are food insecure?
A
20%
1
Q
Competing brain parts in dealing with stress? Maturity age?
A
PFC- cognition/judgment (maturity at 24 yrs)
Amygdala- emotional/impulsive (maturity at 18yrs)
2
Q
Alloantigen
A
antigen that body reacts to from same species
ex. HLA
3
Q
Septic shock?
A
Blood infection from cytokines
LPS binds TLR of MAC in liver/spleen –> TNF-a release —> platelet activating factor form endothelium –> widespread clotting
4
Q
Hematopoietic stem cell differentiates into? (3)
A
- lymphoid progenitor (–> T/B/NK cells)
- myeloid progenitor (–> granulocytes and monocytes)
- erythroid megakaryocyte progenitor (–> platelets and RBC)
5
Q
B cell activation signals?
A
- MHC-II/antigen (B cell) - Th2
- CD40L (Th2) - CD40 (B cell)
- IL-4 binds IL-4 receptor of B cell
6
Q
Describe affinity maturation
A
During B cell differentiation
follicular DC present antigen to B cells; only those with highest affinity will survive
7
Q
Where is neutrophil recruited from during infection?
A
Bone marrow
8
Q
What receptor does IL-8 bind? what cell?
A
CXCR1/2 on neutrophil
9
Q
TLR:
- cell
- binds?
- effect/process
A
- c: DC/MAC/infected cells
- b: antigen (PAMP)
- p: antigen processing
10
Q
B7:
- cell
- binds?
- effect/process
A
- c: DC/MAC
- b: CD28 of T cell
- p: T cell activation
11
Q
CD28:
- cell
- binds?
- effect/process
A
- c: T cell
- b: B7 of MAC/DC/or infected cell?
- p: T cell activation
12
Q
TCR:
- cell
- binds?
- effect/process
A
- c: T cell
- b: antigen/MHC-II
- p: T cell activation
13
Q
CD40L:
- cell
- binds?
- effect/process
A
- c: Th cells
- b: CD40 on B cells and MAC
- p: B cell activiation and MAC optimization
14
Q
CD40:
- cell
- binds?
- effect/process
A
- C: MAC and B cells
- B: CD40L
- P: MAC optimization and B cell activation
15
Q
BCR:
- cell
- binds?
- effect/process
A
- C: B cell
- B: pathogen
- P: B cell antigen processing
16
Q
CR2:
- cell
- binds?
- effect/process
A
- C: B cell (receptor)
- B: C3d of pathogen
- P: antigen processing in B cell; activates TK
17
Q
C3d:
- cell
- binds?
- effect/process
A
- C: pathogen
- B: CR2 of B cell
- P: B cell antigen processing; activates TK
18
Q
CD19:
- cell
- binds?
- effect/process
A
- C: B cell
- B: gets phosphorylated by TK after antigen binding
- P: B cell antigen processing; allows for aB production
19
Q
ITAM:
- cell
- binds?
- effect/process
A
- C: B cell
- B: phosphorylated by TK after antigen binding
- P: B cell antigen binding
20
Q
CDC6
A
- binds ORC (origin replication complex) during G1 phase (inhibits DNA replication
- is phoshorylated and degraded in S phase (S-Cdk promotes this)
21
Q
ORC
A
origin recognition complex (hangs out on DNA)
gets phosphorylated in S phase before replication
22
Q
MCM
A
binds ORC (origin recognition complex) and DNA at end of G1 (required for replication) removed by G2 (after replication)
23
Q
what makes up pre-RC?
A
prereplicative complex
MCM + ORC + DNA + cdc6
(removal of cdc6 –> RC)
24
B cell activation signals?
1. MHC-II/antigen (B cell) - Th2
2. CD40L (Th2) - CD40 (B cell)
3. IL-4 binds IL-4 receptor of B cell
25
Describe affinity maturation
During B cell differentiation
| follicular DC present antigen to B cells; only those with highest affinity will survive
26
Where is neutrophil recruited from during infection?
Bone marrow
27
What receptor does IL-8 bind? what cell?
CXCR1/2 on neutrophil
28
TLR:
- cell
- binds?
- effect/process
- c: DC/MAC/infected cells
- b: antigen (PAMP)
- p: antigen processing
29
B7:
- cell
- binds?
- effect/process
- c: DC/MAC
- b: CD28 of T cell
- p: T cell activation
30
CD28:
- cell
- binds?
- effect/process
- c: T cell
- b: B7 of MAC/DC/or infected cell?
- p: T cell activation
31
TCR:
- cell
- binds?
- effect/process
- c: T cell
- b: antigen/MHC-II
- p: T cell activation
32
CD40L:
- cell
- binds?
- effect/process
- c: Th cells
- b: CD40 on B cells and MAC
- p: B cell activiation and MAC optimization
33
CD40:
- cell
- binds?
- effect/process
- C: MAC and B cells
- B: CD40L
- P: MAC optimization and B cell activation
34
BCR:
- cell
- binds?
- effect/process
- C: B cell
- B: pathogen
- P: B cell antigen processing
35
CR2:
- cell
- binds?
- effect/process
- C: B cell (receptor)
- B: C3d of pathogen
- P: antigen processing in B cell; activates TK
36
C3d:
- cell
- binds?
- effect/process
- C: pathogen
- B: CR2 of B cell
- P: B cell antigen processing; activates TK
37
CD19:
- cell
- binds?
- effect/process
- C: B cell
- B: gets phosphorylated by TK after antigen binding
- P: B cell antigen processing; allows for aB production
38
ITAM:
- cell
- binds?
- effect/process
- C: B cell
- B: phosphorylated by TK after antigen binding
- P: B cell antigen binding
39
CDC6
- binds ORC (origin replication complex) during G1 phase (inhibits DNA replication
- is phoshorylated and degraded in S phase (S-Cdk promotes this)
40
ORC
origin recognition complex (hangs out on DNA)
| gets phosphorylated in S phase before replication
41
MCM
```
binds ORC (origin recognition complex) and DNA at end of G1 (required for replication)
removed by G2 (after replication)
```
42
what makes up pre-RC?
prereplicative complex
MCM + ORC + DNA + cdc6
(removal of cdc6 --> RC)
43
pyrogens impact brain how?
hypothalamus --> signals a. pituitary via CRH --> signals adrenals via ACTH --> release of glucocorticoids --> turn down immune response and enhances liver APR
44
process of stem cell differentiation: starting with totipotent cell?
--> pluripotent (embryo, placenta, amniotic sac) --> multipotent cell (restricted to ecto, meso, or endoderm) --> unipotent cell
45
Trophoblast -->?
placenta
46
Review T cell devo
See notes
47
4 cytokine families?
Type I- short chain (EPO/leptin ect) and long chain (IL)
TypeII helical- IL (we didnt talk about) and IFNs
IL-1 family
TNF family
48
Review complement system
see notes
49
Review Cell cycle
See notes
50
Review DNA replication
See notes
51
Review leukocyte adhesion and entry
See notes
52
Review apoptosis pathways
See notes
53
Review immuno pathways
see notes
