Miscallaneous

Question 1

Asparaginase

Answer 1

Hydrolyzes serum asparagine, depriving tumor cells of the asparagine necessary for protein synthesis, leading to cell death.

Question 2

Hydroxyurea

Answer 2

inhibits ribonucleotide reductase and leads to depletion of deoynuceloside triphosphate pools. DNA synthesis is thereby inhibited. Kills cells in S phase and is given orally.

Question 3

Interferon-alpha

Answer 3

approved for hairy cell leukemia, CML, malignant melanoma, and Kaposi’s sarcoma (endothelial tumor caused by HHV-8 virus.