Miscellaneous

Question 1

Prevention of acute mountain sickness?

Answer 1

Aceazolamide

Question 2

Pharmacological treatment of high altitude pulmonary oedema?

Answer 2

Oxygen, dexamethasone, nifedipine, phosphodiesterase type V inhibitors (Sildenafil)

Question 3

Pharmacological treatment of high altitude cerebral oedema?

Answer 3

Dexamethasone

Question 4

Hereditary Angioedema
-Inheritance pattern
-Low plasma levels of what protein
-Aetiology

Answer 4

-Autosomal Dominant
-C1 inhibitor protein
-Uncontrolled release of Bradykinin

Question 5

Pharmacological Tx for Porphyria cutanea tarda (PCT)?

Answer 5

Chloroquine

Question 6

Diagnostic Biopsy for Amyloidosis?

Answer 6

Tissue treated with Congo red stain, when combined with polarised light makes the proteins appear apple-green on microscopy

Question 7

What are the three types of Amyloidosis?

Answer 7

1) AL Amyloid -> (Light chain fragment -> Myeloma, Waldenstroms, MGUS)
2) AA Amyloid (A for precursor serum Amyloid -> chronic infection)
3) B2 Microglobulin Amyloidosis -> Precursor protein is B2 microglobulin (Associated with patients on renal dialysis)

Question 8

Alpha 1 Antitrypsin (A1AT) deficiency
-Lack of what inhibitor?
-Inheritance?
-M, S, Z
-Pathophysiology?

Answer 8

-Protease
-Autosomal recessive/Co-dominant
-M (Normal). S (Slow), Z (V.slow)
-Glutamate to Lysine mutation