whats shelf life?
time needed for C0 to fall by 10%
(C= 90/100 C0)
second order
eqns = diff for potent drug! (95% instead)
How to solve issues with powder flow?
for.. coarse powder from a hygroscopic material. The powder particles are spherical with a narrow size distribution.
dry the powder!
solving issues:
1. remove small parts- sieving and granulate
2. spray dry = reg shaped, control roughness
3. dry powder- reduce cohesion
4. increase flow promotion- excipients (lubricants, glidants, anti-adherents)
Use mechanical assistance
how to find order of reaction without graph?
- pick 2 pairs of results
- try zero order: C1-C2 / t1-t2
try first order: lnC1-lnC2 / t1-t2
try second order: 1/C1 - 1/C2 / t1-t2which one has points closest? = order - then use equations above to find k specific for that reac
e.g. first order = lnC1-lnC2 / t1-t2
any 2 points
units. … sub into..
zero: conctime-1
first: time-1
second: conc-1time-1
what type of granules can be used in sachets if MR required?
coated granules
Adding an excess of talc to a powder blend prior to tableting will lead to what?
reduced dissolution rate
- Which ONE of the following statements about ocular drug delivery is CORRECT?
A. Drugs can reach the back of the eye directly through the blood retinal barrier
B. Drugs administered topically to the eye reach the aqueous humour through the cornea
C. Ocular drugs can be eliminated from the vitreous humor via diffusion into the posterior chamber
D. Ocular drug elimination can occur via the anterior route across the blood retinal barrier
E. The diffusion of drugs from the systemic circulation into the posterior segment of the eye is restricted by the vitreous
Drugs administered topically to the eye reach the aqueous humour through
the cornea
Drugs administered topically to the eye reach the aqueous humour through
the ??
cornea
Additives in the plastic can leach into the contained product T/F?
true
Vegetative bacteria can be killed easily with what?
hot water
