MOD 10

Question 1

what does ASD involve?

Answer 1

rare de novo mutations and polygenetic risk

Question 2

for ASD what early disruptions are there?

Answer 2

neuronal migration, synaptogensis and cortical layering during early brain development

Question 3

what motor devlopemental impact have on ASD?

Answer 3

delays in gross and fine motor milestones, atypical motor planning and coordination, motor signs may precede social-communication symtoms

Question 4

how does CP result from?

Answer 4

disruptions in brain devleopment during the second or third trimester, periventricular leukomalacia or cortical malformations

Question 5

what is the motor development impact of CP?

Answer 5

non progressive motor impairment due to early brain injury, affects muscle tone, posture and voluntary movement, mild clumsiness to severe spasticity and immobility

Question 6

what is Down syndrome caused by?

Answer 6

trisomy of chromosome 21

Question 7

what is the embryological relevance of down sydrome?

Answer 7

impacts neurogenesis, synaptic developement, and cerebellar growth

Question 8

what is the motor development impact of down syndrome?

Answer 8

delayed motor milestones, hypotonia and ligamentous laxity, requires early intervention and pt

Question 9

what is the genetic influence of spina bifida?

Answer 9

genetic susceptibility and enviroronmental factors

Question 10

what is the embruological relevance of spina bifida?

Answer 10

failure of neural tube closure during weeks 3-4 of gestation

Question 11

what is the motor development impact of spina bifida?

Answer 11

lower limb weakness or paralysis, orphopedic compleications, may require mobility aids, surgical repair, and lifelong therapy