Mod2-Obj7: Skin repairs

Question 1

Skin wounds: Minor wounds

Answer 1

Involve just epidermis

Question 2

Skin wounds: Major wounds

Answer 2

Involve both dermis and epidermis

-2&3rd degree burns

Question 3

Skin damage due to burns

Answer 3

May lead to tissue damage, denatured proteins, cell death

• Loss of skin function
• Immediate threat due to dehydration and electrolyte imbalance
• Renal shutdown and circulatory shock
• Infection via bacteria, fungi and other pathogens

Question 4

3rd degree burns most severe

Answer 4

• Entire thickness of skin damages
• No initial pain (nerve endings destroyed)
• Skin grafting

Question 5

Skin repair

Answer 5

Can be restored to normal if:

• Damage is minor
• Tissue has stem cells to regenerate lost tissue
• Regeneration

Question 6

Extensive tissue damage leads to…

Answer 6

• Repair by fibroblasts
• Scar formation
• Fibrosis

Question 7

3 stages of skin repair

Answer 7

1. ) Inflammation and formation of blood clot
2. ) Formation of granulation tissue
3. ) Regeneration and fibrosis of epithelium

Question 8

Skin repair: Stage 1- Inflammation and formation of blood clot

Answer 8

• Severed blood cells bleed
• Inflammatory chemicals released
• Local blood vessels become more permeable
• Macrophages, fluid and clotting proteins seep into injured area (leaky capillaries)
• Clotting occurs to stop blood loss and hold wound together (surface dries to form a scab)

Question 9

Skin repair: Stage 2-Formation of granulation tissue

Answer 9

• Blood clot is replaced by granulation tissue, composed of new capillaries, fibroblasts and macrophages
  1. ) Capillaries: restore blood supply
  2. ) Fibroblasts: Produce collagen fibres that bridge the gap
  3. ) Macrophages phagocytise cell debris and blood clot

Question 10

Skin repair: Stage 3-Regeneration and fibrosis of epithelium

Answer 10

• Fibrosed are matures and contracts-forming scar tissue
• Epithelial stem cells divide to replace and generate epithelium
• Scab falls off