Def MODS ?
P 138 OH icu
Aetiology MODS
Pathogenesis MODS
Name pathogenic processes involved
List inflammatory mediators MODS ?
Def CARS?
Def SIRS
What happens with the coagulation in MODS?
What Neurohumoral changes ?
Fig 17.2 OH
What macrocirculatory changes?
Vascular tone reduced
NOS production
Micro circulatory changes ?
Apoptosis in MODS?
Increased
Mitochondrial fx
Change in function and reduction in use
Fails to utilize O2
Comorb
More co morb worse MODS
Genetics
Gene expression IL differences
Iatrogenesis ?
Increases risk MODS
GUT?
Drive for MODS
Motor
Clinical features ?
Presence of sirs
with progressive physiological dysfunction of two or more organs
What are management principles MODS