Module 12

Question 1

R&D blueprint

Answer 1

• Prioritization for urgent activities
• ID priorities
• Promote collaborative research
• ID networks and capacity gaps
• Prep tools and frameworks
• Explore funding models
• Monitor and evaluate

Question 2

Prioritization elements

Answer 2

• Transmissibility
• Case fatality rate
• Spillover potential
• Evolutionary potential
• Available countermeasures
• Detection/control difficulties
• Potential scope/societal impacts

Question 3

SARS

Answer 3

• HUGE – 30K long
• Viral envelope = spike (peptidase domain of AcE-2 contains receptor binding domain), envelope, membrane
• Research = antiviral, vaccine, pathogenesis research, virus stability

Question 4

NIPAH

Answer 4

• Pleomorphic + negative sense + non-segmented
• Detect through symptoms, isolation, RT-PCR, ELISA
• No vaccine
• Possible genetic manipulation since published

Question 5

EBOLA

Answer 5

• Negative sense + ssRNA
• Doesn’t spread through food, water, air, anthropods
• Detection: few days (ELISA, PCR, isolation), recovery (IgM, IgG), dead (immunohistochemistry, PCR, isolation)