Module 14

Question 1

Describe the conventional approach of guiding self-organization

Answer 1

Identify a mechanism of “animal” organogenesis in vivo. Then by deducing culture conditions for “human” organoid-genesis in vitro from hPSCs.

Question 2

What are the 3 processes of multicellular self-organization?

Answer 2

1. Self-assembly or Sorting Out
2. Self-patterning
3. Self-morphogenesis

Question 3

What are the two advantages of organ-on-a-chip devices?

Answer 3

1. Provide physiologically reasonable microenvironments
2. Provide spatiotemporal controlled microenvironments