Module 4 Tissue Integrity

Question 1

What is tissue integrity?

Answer 1

The state of structurally intact and functioning skin and mucous membranes

Question 2

Define regeneration

Answer 2

Damaged cells are replaced by the division of remaining viable cells of the same type

Question 3

What is resolution?

Answer 3

Damaged cells are reversibly injured and recover

Question 4

What is an example of a cell being reversibly injured?

Answer 4

E.g. swelling r/t o2 deprivation —> stops ATP synthesis —> muscle cell stops contracting

Question 5

What does tissue repair mean?

Answer 5

Damaged cells are replaced by scar tissue; cells can’t regenerate r/t extensive damage OR chronic injury and regeneration can’t keep up

Question 6

What is the negative side effects of tissue repair?

Answer 6

• Loss of function
• cosmetic

Question 7

What cells cannot regenerate?

Answer 7

Neurons, cardiac muscle cells

Question 8

Will healing following an MI occur by resolution, regeneration, or repair? (Answer for zone of ischemia, zone of injury, zone of infarction)

Answer 8

• Zone of ischemia: cells are not injured, healing is not necessary, O2 is restored
• Zone of injury: will heal by resolution
• Zone of infarction: will heal by repair

Question 9

What is primary intention?

Answer 9

• wound margins are held closely together
• healing occurs from the edges in

Question 10

What is secondary intention?

Answer 10

• Wound margins are not well approximated
• healing occurs from the bottom up

Question 11

What is tertiary intention?

Answer 11

Wound is intentionally left open because of infection, contamination, swelling etc.