Module 5
Electrophysiological Treatment of Cardiac Arrhythmias
Topics
- Abnormal rhythms
- Brugada syndrome
- Troponin levels
- Non-operating room anesthesia “NORA”
- Electrophysiology procedures lab (“EP lab” or “cath lab”)
- Pacemakers & AICDs
- Intra-aortic balloon pumps (IABP)
Abnormal Rhythms in the Operating Room
Answers:
1. Atrial fibrillation
2. Atrial flutter
3. Ventricular tachycardia
4. electrocardiography
Atrial Fibrillation (Afib)
Answers:
1. flutter
2. atrial contraction
3. ventricular rate
4. Irregular
Atrial Flutter
Answers:
1. ventricular
2. saw-toothed
3. Vagal maneuvers
Left Bundle Branch Block (LBBB)
Answers:
1. pulmonary artery catheter
Ventricular Tachycardia
Answers:
1. external defibrillator pads
2. wave difficult
3. synchronized cardioversion
4. defibrillation
Ventricular Tachycardia/Torsades
Answers:
1. 150–250
2. difficult
3. the electrolyte disturbance
Brugada Syndrome
Answers:
a. sudden death
b. dominant
1. right bundle-branch block and ST-segment elevations
2. isoproterenol
Troponin Levels
Answers:
1. blood stream
a. T and I
b. 24 - 48
c. 3
EP Lab
Answers:
a. diagnostic
b. therapeutic
1. soapme
Anesthesia Considerations
Answers:
1. general anesthesia
Pre-operative Assessment
- Standard 12 lead ECG is performed for risk assessment
- Baseline for chronic or acute myocardial ischemia and/or arrhythmias; comparing ECG’s is important
- Both myocardial ischemia and arrhythmias are common following _______(1); post-operative 12 lead ECG is often obtained in high _______(2) patients.
Pre-op Focus
- Airway - identify challenges which may be amplified in _______(3) environment
- Previous anesthetics - review management with focus on sensitivity to _______(4)
- Allergies - focus on shellfish (contrast dye), fish (protamine), _______(5)
- Cardiac hx - note EF, CHF (ability to tolerate supine position), arrhythmia classification, pulmonary HTN (avoid _______(6) and hypoxemia)
- OSA/morbid obesity - important if _______(7) planned
- Positioning - peripheral neuropathy, back pain- peripheral extremity _______(8)/padding
- GERD - important if sedation planned
Answers:
1. CVOR
2. cardiac risk
3. NORA
4. sedatives
5. antibiotics
6. hypercapnia
7. sedation
8. position/padding
A “Typical” Anesthesia Plan
- Airway management
- Intubations performed with a glidescope to decrease chance of airway trauma
- Heparinization during the procedure may lead to airway bleeding -> impacts extubation!
- Mac cases: must be prepared for emergent intubation (with a glidescope)
- Have nasal airways easily accessible
- Induction technique: if EF <40% consider using _______(1) (or etomidate + propofol)
EP Lab Example of Anesthetic Plan
For an EF > 30 %
Fentanyl 250 mcg
Phenylephrine 50 mcg
Lidocaine 100 mg???
Propofol
Consider midazolam, if necessary, to reduce anxiety
For an EF < 30 %
Ketamine 150 mg
Phenylephrine 100 mcg
Lidocaine 100 mg????
Propofol
Consider midazolam, if necessary, to reduce anxiety
High Frequency Jet Ventilation
- Used to minimize respiratory movement during AF ablation
- Decreases atrial motion, promotes intra-cardiac instrument stability
- Should be a joint decision with the electrophysiologist in advance
- Requires GA with ETT and _______(2)
Answers:
1. midazolam
2. TIVA
Anesthetic Plan (con’t)
- The electrophysiologist may prefer to avoid certain anesthetics, as some agents may suppress an arrhythmia. It is important to discuss this at the start of each case.
- Very light anesthetic is desirable when trying to elicit a premature ventricular contraction or ventricular tachycardia in order to determine the focus from which the arrhythmia is arising.
- In most general anesthesia cases, inhalational agents should be avoided because of _______(1) effects
- AVOID ______(a)-acting muscle relaxation to help monitor phrenic nerve activity
- Consider using only remifentanil and no _______(2)
Patient Positioning
- An arterial line should be placed on the opposite side from which the electrophysiologists operate in case adjustment is needed
- A ______(b) should be placed for possible cardioversions/________(3)
- Double check proper position of extremities as arms are typically tucked at sides
- Patients are not paralyzed.
- With cardioversion/defibrillation, there can be significant muscular contracture wrists must be restrained and extremities _______(4)
- Access to the stopcocks, IV lines and monitors will be limited once the patient is draped
Shared-medication Administration
- Cardiology nurses may be assigned to administer various medications
- Heparin, vasoactive inotropes
- Cardiologists may administer drugs directly into cardiac catheters
- Nitroglycerine, calcium channel blockers
- Hemodynamically-acting meds and anesthetics may interact with procedure
- _______(5) IS PARAMOUNT
Answers:
1. anti-arrhythmic
a. long
2. midazolam
b. soft bite block
3. defibrillations
4. padded
5. COMMUNICATION
ISUPREL Challenge
- One of the most difficult times in managing hemodynamics is when the electrophysiologist wishes to evaluate the induction of an arrhythmia using increasing doses of _______(1).
- Normally _______(1) is started at 3 mcg/min by the eps lab _______(2) and titrated to 6, 12, 20, 30 mcg/min, although the dosing is variable.
- This typically produces a significant loss of _______(3) and drop in ______(a)
- The anesthesiologist will likely need to start phenylephrine to support a SBP _______(4)
Answers:
1. isuprel
2. nurses
3. peripheral resistance
a. blood pressure
4. 130-140
5. increase
b. rebound hypertension
Hemodynamic Management
- Patients may become part extremely labile hemodynamically.
- Reactions to these drastic changes at times needs to be tempered (look for underlying cause of vital sign instability) as well as determine when rapid intervention is needed
- Electrophysiologists are very involved in the patient’s hemodynamic management
- When needed, can control the heart rate with pacing or cardioversion
- Communication is critical, particularly when making significant changes to the level of anesthesia
- ______(a) may be caused by tamponade or retroperitoneal bleeding and masking these changes with medication can delay a timely diagnosis.
- In the routine case, the patient will receive a large amount of volume by the electrophysiologist during the ablation process, so fluid management by anesthesia should be conservative
Post-op Considerations
- Pain generators
- Back pain/extremity pain for _______(1) supine for prolonged period
- Foley catheter
- Intravascular catheters in groin, need to hold pressure
- Typical pain medications:
- _______(2) typically given (caution in renal impairment)
- Morphine/dilaudid to be considered
- Ondansetron for PONV
Okay… What are we doing??? Electrophysiologic Procedures (EP) Lab
- Localize the site of origin or pathway of arrhythmias
- Isolate or destroy the tissue
- Improve scar tissue within the conduction pathway
- Apply energy through a catheter using radiofrequency, ultrasound, laser, microwave energy or cryoablation
Answers:
a. Hypotension
1. laying
2. KETOROLAC
EP Procedures and Locations
EP Cases outside the EP lab
- Cardioversions
- TEE
- Non-Invasive Programmed Stimulation (NIPS)
- Defibrillator Threshold Testing (DFT)
EP Cases in the EP lab
- Arrhythmia device placement
- Radiofrequency Ablation (RFA)
- Lead extraction cases (for leads in place for less than one year; otherwise, performed in the OR)
Cardioversions
- Cardioversions require about ~ 15 minutes
- Generally take place outside of the EP lab
- Short period of deep sedation/general anesthesia, usually using bolus dose of propofol/etomidate depending on ejection fraction
- A _______(1) should be placed
Answer
1. soft bite block
Transesophageal Echocardiogram
- Complete TEE require ~ 60 minutes
- More prolonged sedation may be required in some TEE patients who are unable to tolerate the procedure with the usual non-anesthesiology provider
- Blunt ______(a) reflex (may topicalize with _______(1) spray)
- Keep airway open (chin lift/jaw thrust, soft _______(2) if necessary)
Non-Invasive Programmed Stimulations (NIPS)
- NIPS require ~20 minutes; requires _______(2)
- Programmed pacing stimulation in an attempt to elicit ventricular arrhythmias.
- This usually occurs 1-2 days post VT/VF ablation.
- If the icd functions properly, it will anti-tachycardia pace or shock the patient out of the arrhythmia.
- If not, external defibrillation/cardioversion with high joule shocks may be needed.
- In either case appropriate sedation/general anesthesia will be required.
Defibrillator Threshold Testing (DFT)
- DFT require ~ 20 minutes
- Often (but not always) performed at the time of ICD placement within the EP lab.
- The anesthetic approach requires appropriate sedation/general anesthesia.
- A _______(2) is required to prevent lacerations or injury to the tongue and inside the cheeks.
Answers:
a. gag
1. cetacaine
2. soft bite block
Radio Frequency Ablation
- RFA can identify mechanisms of ______(a) and map out _______(1) foci (anatomically and also in relationship to the EKG) with subsequent catheter-directed ablation via radiofrequency energy.
Answers:
a. tachyarrhythmias
1. arrhythmogenic
2. re-entrant
3. epicardial
4. transseptal
5. increases
Anesthetic Considerations for RFA
- MAC may be possible, but GA is typical due to long duration of the procedure; absence of movement is required.
- Arterial line is necessary
- Esophageal temperature monitoring: an acute increase of 1°C requires a WARNING!
- Cool the catheter tip
- Constant vigilance for pericardial tamponade
- Always be prepared to convert to a GA
- Wide variety in length, complexity and critical nature of arrhythmia
- A thorough discussion with electrophysiologist is warranted
- Surface defibrillator/pacing pacer should be applied in all cases with a functioning defibrillator available
- Some arrhythmias are frequently medication/sedation-sensitive and the electrophysiologist may wish to give NO sedation at the beginning or throughout the case
- May use solely _______(1) infusion in these cases
- LV assist devices (ex. Impela) may be placed during the procedure for patients with low EF or severe VT
- If LV assist device is used, _______(2) should be employed
Answers:
1. remifentanil
2. cerebral oximetry
RFA Procedures
1. _______ (1)
- Require ~2 – 4 hours
- MAC or mild- moderate sedation, need sedation bolus for local _______ (2) access and if _______ (3) placed
2.______(a)
- Require ~6 – 10 hours
- Generally GA with ETT and anesthesia machine _______ (4) versus jet ventilation, radial _______ (5)
3. ______(b)
- ~ 6 – 10 hours
- Most complex – start with MAC during the mapping phase.
- Assess mental status during VTach to determine need to _______ (6)
- Patient factors may preclude MAC (anxiety, obesity).
- Use _______ (7) to determine need to treat hypotension
4. Femoral arterial access (may not need radial _______ (8)), if patient unstable at end of case, may need radial A-line for post-op care
- GA with ETT during RFA ablation or _______ (9) approach
RFA Complications
1. Vascular (hematoma, bleeding, vascular injury)
2. Cardiac tamponade, perforation (True Emergency- may require _______ (10) or perfusion)
3. Complete heart block
4. Line insertion related (air embolism or pneumothorax)
5. Airway trauma/hematoma due to traumatic intubation followed by heparinization
6. Nerve palsy as a result of improper positioning
7. Esophageal stricture/perforation
- Risk reduction: _______ (11) is positioned directly behind the ______(c) with fluoroscopic guidance and temperature closely monitored particularly during ablation
8. Phrenic nerve injury
- The electrophysiologist can avoid harming the phrenic nerve by identifying its location with pacing and observing where the pacing causes the diaphragm to move — avoid _______ (12)
Answers:
1. Supraventricular tachycardia (SVT), atrial flutter or WPW
2. femoral
a. Atrial fibrillation
3. foley catheter
4. ventilator
5. arterial line
b. VTach or PVC mapping
6. cardiovert
7. cerebral oximetry
8. a line
9. epicardial
10. window
11. esophageal temperature probe
c. atrium
12. muscle relaxants
Arrhythmia Device Placement
1. Permanent pacemaker (PPM) for symptomatic _______ (1)
2. Implantable cardioverter-defibrillator (ICD) for _______ (2)
3. Devices capable of cardiac resynchronization therapy (CRT)
Types of procedures:
- placement, generator/battery changes, lead placements, defibrillator testing (DFT), 1 loop placement in superficial abdominal area, subcutaneous (along the sternum) placement of AICD with abdominal wall generator placement
- Most cases are performed via a _______ (3) approach with the generator implanted in pectoral region
- Cases infrequently performed via an _______ (4) approach (5%)
4. Anesthetic approach to arrhythmia device placement (2 to 4 hours)
- Typically MAC cases requiring mild to moderate sedation: fentanyl/midazolam with local or infusions of _______ (5)/remifentanil
- BIV ICD placements may require GA under certain circumstances (ex. OSA, intolerance of supine position)
5. Antibiotic prophylaxis per guidelines
6. Occasionally patients require a conversion to GA _______ (6) (prepare ahead of time)
7. Perforation of heart with _______ (7) is an infrequent but known risk, so be prepared for volume expansion and vasoactive medication resuscitation
Answers:
1. bradycardia
2. tachyarrhythmias
3. transvenous
4. epicardial
5. propofol
6. EMERGENTLY
7. tamponade
Team Approach to CIED
Table 1: Essential information to be communicated to the perioperative team by the CIED specialty team
Answers:
1. pacemaker
2. Device type
3. device placement
4. longevity
5. programming
6. pacemaker
7. magnet
8. threshold
9. factors
CIED Terms
Types of CIEDs
Anesthetic Considerations for CIED
Answers:
1. Bradyarrhythmias
2. Tachyarrhythmias
3. systolic dysfunction
4. single
5. dual
6. bi-ventricular
7. coronary sinus on the left ventricle
8. CV disease
9. transcutaneous cardiac pacing pads
10. lidocaine
11. MAC
12. GA (general anesthesia)
13. painful
14. INR
15. 100% pacer
a. before
16. defibrillate
Pacemakers
Effects of Magnets on Pacemakers
Pacemakers Considerations
Answers:
1. electrically
2. Single-chamber
3. Dual-chamber
4. asynchronously
5. power
6. short bursts