1
Q
Moraxella bovis disease in bovines
A
Infectious bovine keratoconjunctivitis or ‘Pink eye’
Serous to purulent conjunctivitis and keratitis
Highly infectious
2
Q
Moraxella bovis Virulence Factors
A
Fimbriae - adhesion to host cell (eye), conjunctival and corneal epithelial cells
Capsule
LPS
Exotoxins - cytotoxin, pore forming toxin
3
Q
Moraxella bovis Pathogenesis
A
- Speific attachment of bacteria to conjunctival/corneal epithelial
- Production of toxin
Destruction of tissue - Inflammation
- Further growth and production of toxins
- Increased susceptibility for other pathogens
- Non infectious damage, dust
Irreversible eye damage
4
Q
Moraxella bovis Predisposing Factors
A
Young cattle
Flies
Eye irritation (dust, sun)
Bovine herpesvirus 1
5
Q
Moraxella ovis
A
Associated with keratoconjunctivitis in bovines, sheep
Associated with pneumonia in bovines, sheep
