What are the 4 preferred ORAL agents for trx of SSTIs due to MRSA in adults?
- TMP-SMX 1 or 2 DS tabs BID
- Clindamycin 450 mg PO TID
- Doxy 100 mg PO BID
- Minocycline 200 mg once, the 100 mg po bid
What is the PO ALTERNATIVE for SSTI caused by MRSA?
- Linezolid 600 mg PO BID
What is the preferred PARENTERAL trx of SSTI due to MRSA in adults? (2)
-specify dosing in mg/kg and frequency
- Vanco 15 to 20 mg/kg/dose q8-12 hrs
- Daptomycin 4 to 6 mg/kg IV once daily
What are three other ALTERNATIVE PARENTERAL options for SSTI caused by MRSA?
Alternative agents:
Linezolid 600 mg IV or PO BID
Telavancin 10 mg/kg IV once daily
Dalbavancin 1500 mg IV once
Ceftaroline/Ceftobiprole (5th gen cephs)
What are the 10 Abx that COVER MRSA?
1) TMP-SMX (PO) –> think: this one has a TEMPER so it’s scary enough even for MRSA.
2) CLINdamycin (PO)
3) LINezolid (IV or PO)
2 glycopeptides:
4) Vancomycin (IV0
5) Daptomycin (IV)
2 Tetracyclines:
6) DoxyCYCLINE (po)
7) MinoCYCLINE (po)
2 “-vancins”; lipoglycopeptides
8) TeleVANCIN (iv)
9) DalbaVANCIN (iv)
10) 5th gen cephalosporins (ceftobiprole/ceftaroline)
What is the acornym to remember the PO and IV abx against MRSA?
CCLIN-TT + glyco and lipoglycopeptides.
C (cephalosporins) CLIN (clinda and linezolid)-T T (TMP-SMX & Tetracycline) + glycopeptides (vanco—) + lipoglycopeptides (the -vancins)
