MS

Question 1

Clinical Features of MS

Answer 1

Pyramidal dysfunction
Optic neuritis
Sensory symptoms (Dorsal column loss)
Lower urinary tract dysfunction
Cerebellar dysfunction
Fatigue

Question 2

Clinical course of MS

Answer 2

Relapsing remitting
Secondary progressive
Progressive relapsing
Primary progressive

Question 3

Treatment of fatigue

Answer 3

Amantadine

Modafanil (if sleepy)

Question 4

DMT - First line

Answer 4

Interferon - Avonex, Rebif, Betaseron

Tecfedira - first line in RR MS

Question 5

DMT - Second line

Answer 5

Monoclonal Antibody

• Fingolimod

Question 6

DMT - Third line

Answer 6

Mitoxantrone (Relapsing progressive MS)

Question 7

Tysabri

Answer 7

Used in highly active RR MS.

high disease activity despite treatment with an interferon

Question 8

Baclofen

Answer 8

GABA derived drug

Antispasmodic

Question 9

Oxybutinin

Answer 9

Anticholinergic

Used in detrusor instability and urinary incontinence in MS.

Question 10

Propranolol

Answer 10

Beta blocker to help with tremor