MSK

Question 1

What are the indications for colchicine?

Answer 1

It is second line treatment for gout

Question 2

What is the mechanism of action for colchicine?

Answer 2

• disrupts tubulin leading to the down regulation of multiple inflammatory pathways
• also leads to down regulation of innate immunity
• inhibits phagocytosis
• inhibits leukocyte migration to joints
• decreases the release of uric acid

Question 3

When should colchicine be used with caution?

Answer 3

• cardiac disease
• the elderly
• GI disease

Question 4

What are the common side effects of colchicine

Answer 4

• abdo pain
• diarrhoea
• nausea
• vomiting