MSK

Question 1

base of thumb pain suggests…

Answer 1

osteoarthritis

Question 2

what is osteomyelitis

Answer 2

infection of the bone

Question 3

2 inflammatory markers and how they differ

Answer 3

• CRP: rises and fall fairly quickly thus used to show response to tx
• ESR: shows binding to RBCs + rises and falls slowly.
  
  • so demonstrates chronic infection as it is related to the lifespan of an RBC.

Question 4

key investigations for joint infections

Answer 4

• joint aspirate
• blood culture: bacteraemia often seeds joint

Question 5

most common causative bacteria of joint infection

Answer 5

staphylococcus aureus

Question 6

who Is most likely to get an infected joint

Answer 6

RA pts

Question 7

most common causative bacteria of bone infection

Answer 7

staphylococcus aureus

Question 8

5 principles of inflammation

Answer 8

1. redness
2. swelling
3. warmth
4. loss of function
5. pain

Question 9

types of connective tissue disease

Answer 9

• inherited
  
  • Marfans syndrome [can also be developed without fam hx]
  • Ehler Danlos Syndrom
• Autoimmune [inflammatory → scarring and damage of organs affected]
  
  • Systemic Lupus Erythematous [lupus]

Question 10

most common cause of secondary/ metastatic bone cancers

Answer 10

• breast
• lung
• thyroid
• kidney
• prostate

Question 11

gene responsible for spondyloarthropathies

Answer 11

HLA B27

Question 12

general features of Spondyloarthropathies

Answer 12

Sausage digit – dactylitis = swelling of a whole digit. Predictor of underlying bone damage

Psoriasis

Inflammatory back pain -

NSAID – good response

Enthesitis of the heel

Arthritis –distal joint involvement = psoriatic arthritis [or OA]

Crohn’s / colitis / potentially elevated CRP

HLAB27

Eye – uveitis. Anterior uveitis = iritis