1
Q
Wegener granulomatosis- Eti
A
- 12 per million
- 4th-5th decade of life
- M = W
2
Q
Wegener granulomatosis- Sx
A
- Triad of upper & lower resp. tract disease, glomerulonephritis
3
Q
Wegener granulomatosis- Dx
A
- Renal biopsy: Small vessel vasculitis, granulomatous inflammation & necrosis
- c-ANCA- sensitive and specific
- Chest CT- infiltrates, nodules, masses, cavities
4
Q
Churg-Strauss syndrome- Eti/ Sx
A
- Idiopathic vasculitis of small & medium artier in pts with asthma
- Commonly affects skin & lung
- Marked eosinophilia
5
Q
Churg-Strauss syndrome- Dx
A
- Histology: fibrinoid necrotizing epithelioid & eosinophilic granuloma
6
Q
Goodpasture syndrome- Eti/ Sx
A
- Idiopathic, recurrent alveolar hemorrhage & glomerulonephritis
- Abs mediated- anti-glomerular basement memebrane
- Hemoptysis, pulm hemorrhage, anemia,
7
Q
Goodpasture syndrome- Dx
A
- IgG immunofluorescence in glomerulo or alveoli
