LM: Diffuse thickening of glomerular capillary walls*
EM: subepithelial deposits* of electron dense material
“Spike & Dome” appearance*
Membranous GN
LM: normal
EM: diffuse effacement of foot processes, no deposits
Minimal Change Disease
LM: Large, hypercellular glomeruli
Increased mesangial matrix
Double contour or Tram-track appearance
MPGN or Membranoproliferative Glumerulonephritis
LM: focal segment of sclerosis and hyalinosis
EM:
Loss of foot process, epithelial denudation
FSGS or Focal Segmental Glumerulosclerosis