What’s the gold standard of calculating GFR?
Inulin clearance
Why is inulin clearance the gold standard for GFR?
It’s completely filtered by the glomerulus without any renal tubular modification.
Creatinine clearance is different from inulin clearance how?
Creatinine clearance is completely filtered but also secreted by the proximal tubule.
It will overestimate GFR by 10-15 percent
In the proximal tubule - what happens to creatinine ?
Creatinine is 90 percent filtered in the PCT and 10 percent secreted