Neurology

Question 1

What is the MoA of donepazil?

Answer 1

Anticholinesterase

Question 2

Which acetylcholinesterase inhibitors are used in Alzheimer’s?

Answer 2

Donepezil, galantamine and rivastigmine

Question 3

When is donepezil contraindicated?

Answer 3

Bradycardia

Question 4

What does bulbar mean in neurology?

Answer 4

Bulbar refers to the medulla oblongata, a bulb-shaped part of the brainstem responsible for controlling vital functions, especially those related to speech and swallowing

Question 5

What supplies Broca’s area?

Answer 5

Middle cerebral artery
n a right-handed person, language is almost always localised to the left (dominant) hemisphere.

Question 6

How are TIAs treated in the first 21 days, and how does this change after 21 days?

Answer 6

First 21 days - aspirin and clopi
Long term - clopi

Question 7

What imaging should TIA patients have?

Answer 7

Carotid duplex ultrasound, CT angiography or MR angiography
To look for carotid stenosis that may trigger a stroke

Question 8

What would nerve conduction studies show in GBS?

Answer 8

Decreased conduction velocity of motor nerves
(Loss of myelination=slower transmission)

Question 9

What antiplatelets should be given after a stroke?

Answer 9

300mg aspirin for 2 weeks and then clopidogrel 75mg lifelong

Question 10

What are the NICE criteria for a CT head within 1 hour?

Answer 10

GCS <12 after an hour
GCS ,15 after 2 hours
Open / basal skull fracture
More than 1 episode of vomiting
Seizure
Focal neurological defecit

Question 11

What are the NICE criteria for a CT head within 8 hours?

Answer 11

> 65
Bleeding/clotting disorder
Dangerous mechanism of injury
30m retrograde amnesia before th einjury