NIPT

Question 1

When?

Answer 1

Present in maternal blood as early as 5 weeks, and reaches optimal level for analysis at 10 weeks LO 1999

Question 2

Routine screening: 18+21 >99% effective 0.1% FPR

Answer 2

Krypos et al (2012)

Question 3

Limitations

Answer 3

Vanishing twin, placental mosaicism, detect maternal problem, low cffDNS conc (BMI)

Question 4

Not diagnostic, patient declined amnio in favour of NIPT, FP

Answer 4

Smith et al (2013)