NMBE 15 Notes

Question 1

MOA Bosentan

Answer 1

BosENtan
competitively inhibits ENdothelin-1 receptors to reduce pulmonary vascular resistance

AE: Hepatotoxicity

Question 2

Voluntary social withdrawal
Limited emotional expression
Content with social isolation
dx?

Answer 2

Schizoid PD (Cluster A)

Question 3

Hypersensitive to rejection
Socially inhibited
Timid
Feelings of inadequacy
Desires relationships with others

Answer 3

Avoidant PD

Question 4

Left-dominant coronary circulation

Answer 4

PDA arises from LCX (8%)

Question 5

Chlorpheniramine

Class

Answer 5

Antihistamine
Reversible inhibitor of H1 receptor
AE: drowiness, antimuscarinic, anti-alpha adrenergic

Question 6

Major substrate for renal ammoniagenesis

Answer 6

Glutamine

Question 7

Cool, pale extremities
elevated JVP
Crackles over bottom lung fields
weak peripheral pulses
Kind of shock?

Answer 7

Cardiogenic

Question 8

Case control vs cohort studies

Answer 8

Case-control: disease/no disease

Cohort: exposure/no exposure