CPE-
Any type of damage u durced by a cell. Virus induced damage to the cell that alters its microscopic appearance
Examples of CPE(cell shape abd size)
Microscopic analysis- qualitative
Types of CPe
Inclusion bodies, synctia
Inclusion bodies
Areas and damaged host cell organelles in nucleus/cytoplasm. (Green areas in damaged host cell)
Synctia(size)
Fusion of multiple host cells into a single large cells containing multiple nuclei
Explain the term transformation
Process of/effect of inconvenience or cancer causing viruses
How can transformation be caused in host?
Two ways
1) Direct(some viruses carry cancer causing genes)
2) Indirect- some viruses produce proteins that can lead to loss of growth regulations—> cancer
What are the 4 symptoms of transformed cells
1) growth increase
2) chromosomes alterations
3) cell surface milecule changes
4) infinite divide
What are tumor imitating mamal8an viruses called and give an example
Oncovirus
HTIV1
HERPES
PAPILLOVIRUS
HEPATITIS
T-even bacteriophage eats
E coli
Lytic cycle does whay to the bacteria
Kills it
What are the 5 steps of the lyrics cycle
- Attachment
- Penetration-release of phage DNA by sheath, tiny gap created by phage lysozyme
- Synthesis(bio). Phage DNA directs synthesis
- Maturation- phage particles assemble
- ReleSe- lysozyme breaks cell wall
Steps of lysogenic cycle
- Attachment
- Penetration
3) phage DNA- integrates/becomes part if bacterial chromosomes by recombination (becomes prophage) - Lysogenic bacterium- reproduces
- Many cell divisions- bacterium acquires new traits from phages ex. Clostridium botulinum
