Notes from MDACC

Question 1

What is the importance of GATA3

IHC in hematopoietic neoplasms ?

Answer 1

• GATA3 can be positive in high-grade lymphomas

Question 2

If you have a B cell lymphoma with high-grade

morphology and features how should you

top line the diagnosis ?

Answer 2

• Aggressive B cell lymphoma
• Then you can say high-grade B cell FISH is pending and update the report appropriately.

Question 3

What is true about Burkitt Lymphoma

in HIV positive patients ?

Answer 3

• The lymphomas can be nodal
• In HIV negative people they are otherwise extranodal

Question 4

For Follicular lymphoma how are nodules

defined for the follicular pattern ?

Answer 4

• oftentimes we use the CD21 and CD23
• But if morphologically you see a nodular growth pattern, even without good supporting staining of the FDC you should call it follicular growth pattern rather than diffuse

Question 5

What two disease entities should be in the

differential diagnosis if there is marked sinusoidal

involvement of a lymph node ?

Answer 5

• Classic Hodgkin Lymphoma (syncitial variant of the nodular sclerosing subtype)
• Anaplastic Large Cell Lymphoma

Question 6

Should post-treatment Hodgkin’s be morphologically classified ?

Answer 6

• Not in the diagnostic line it shouldn’t because it doesn’t matter since it has relapsed.
• However, the morphology should be described in either the microscopic or in the comment in order to give the clinical team more information and for following the disease later on.

Question 7

What is the cutoff for cMYC staining in evaluating

for positivity in large B cell lymphomas ?

Answer 7

• cMYC positivity should be >40%
• However, the intensity of the staining must be evaluated and commented on as well in the microscopic.

Question 8

What translocation is more often seen in

MALT of the lung ?

Answer 8

• t(11;18)

Question 9

Look up and read about HHV8 Lymphadenitis

(non-neoplastic condition)