1
Q
fever edema and pain
A
arachidonic acid(AA)
head coach cox
various chemical dependent translocation of phosphophilipase A2
hydrolyzes the bond holding the arachidonic acid molecules
PLA2
cascade of inflammatory events
PLA2
hydrolyzes the events
several inflammatory and thrombogenic molecules
cyclo-oxygenase or COX
COX1 is constitutively active in most cells
COX 2 not all the time
COX 1 (inflammation)taking a nap at the dug hotfoot(prostanoids) TXA2 batter's box is synthesized by COX 1 causes vasoconstriction PG(pro slugger) gastric cytoprotective prostaglandins pro-cycler pitching machine
2
Q
COX 2
A
Endothelial COX 2 prostacyclin synthesized by COX 2 Vasodilator inhibit platelet aggregation maintains non thrombogenic function, students clutching plates afferent pro-sluggers kidney function
3
Q
COX 2
A
synthesized prostaglandins that increase vascular permeability
pain, permeability and fever
4
Q
COX 2
A
expression is induced by inflammation
5
Q
COX 1
A
expression is constitutively expressed
6
Q
GOUT,lupus,migraine,tension headache,arithri
A
go BLAC Sox diclofenac ketorolac INDIGO sox indomethacin SOX CAM meloxicam piroxicam
ApPPROXimately110 mph
naproxin
