what are stats on OCP and suicide risk
One review on ½ million women for 8 years (mean age 21 yo) - saw 6999 first suicide effects, and 71 suicide
Double that of non OCP - and tripel for risk of suicide
Risk increased within 2 months
How can affect OCP nutrients?
Nutrient deficiency : Deletes nutrients across board - particularly b6, b12, zinc, magnesium, COq10 , selenium, vit E
How can OCP cause post pill acne?
Post pill acne - 6-12 months after OCP (suppresses sebum) - continues even after pill is stopped (especially when individual comes off OCP)
Gut disruption - to flora (can also contribute to post-pill acne)
Liver health (also can contribute to post pill acne)
Nutrient deficiencies
Endocrinological low [rphesyerpme. Espyrpehm, increased eostrogen)
What are pill bleeds?
- Does not correlate to proper menstruation!!
- Having the occasional pill bleed is necessary to prevent breakthrough but does not mean you have ovulation
Give overview of progestin use in OCPs
- Progestin drugs supposedly similar to progesterone - but
- Used in many OCPs, IUD
Effects thyroid, skin, hair health ect etc etc - Particularly type of progestin linked to depression, hair loss, ,,… this is actually more similarly structure to testosterone than progesterone!
- Progestin only pills - things uterine lining and impairs fluid which also suppressing estrogen - when it was first tested in 1956 it had so many side effects that estrogen had to be added to make it more tolerable!!!!
Why is hair loss common in OCP use?
Some of the progestins have a high androgen index / structural similarity to testosterones
Shrinking hair follicles
Some may not have high androgen index BUT may cause rebound hair loss
What are effects of progestin on health?
Sebum rebound / acne
hair loss
Behaviour sys[toms - anxiety / depression
Affect liver health
Affect hormones - low progesterone, low esotrogen, increased andorgens, increased stress
Give overview of marina IUDs effects
Small amounts of progestin released into uterus
Thickens lining and impairs cervical fluid
Suppresses approx 85% cycles in first year but then only about 15% in years after
Can reduce blood flow by about 90% - often used hen bleeding an issue (but need to understand tradeoffs - we have much better ways to regulate bleeding!!!!)
morena can allow cycles but suppress bleeding
Give overview of flax seed use cases
10g ground flaxseed sig increased the 2:16 ratio in postmenopausal women (when taken for 2 cycles) - favoured 2OH pathway
A lot of flax seed studies are flawed - placebos are not really placebos!!!
Phytogeostrogens = sig higher endometrial thickness, clinical pregnancy and serum progesterone sig higher when phytoestrogens added in days 1-12 follicular stage
Reduced risk of uterine fibroids (by increasing ligand)
what are some risks of OCP use?
- decreases libido / sex thoughts
- increased risk of being prescribed uneneccesary
- increased risk suicide
- incr. risk blood clots
- decr. nutrients (mag, CoQ10, selenium, B6, B12, Vit E)
- post pill acne
Give overview of combined pill
- contains eostrogen and progestin
- can be monophonic or multiphasic
- works by inhibiting ovulation, thickens cervical mucis and alternating endometrial lining
How does oestrogen work for contraception
- flat lines hormones = not having follicle development = decr. GnRH pulses, dear LH and FSH, dear follicle dev, follicle cells = lo LH surge, no oestrogen surge, and FSH surge = no ovulation
-
Whats akasia ?
egg dies
- taken back up by ovary
= no leutinisation, n opprgesteorne surgery, no up regulation, cholesterol
how does progestin work as a contraception?
- thins uterine lining
- decreases LH = decreases androgens = decreases oestrogen
- thickens cervical mucus (road block!)
- no development focllicle = ovulation cant happen again
how do progestin only contraceptions work (mini pill)
- thickens cervical mucus
- inhibits ovulation
- alters endormtiral lining
- slower ovum transport
might be slightly less effective than combined OCP - as breakthrough bleeds have a sightly higher risk of preg
why might some breastfeeding women take mini pill?
- synthetic oestrogen affects milk production = cant take OCP
BUT can have migraines, headaches, risk Prost partam depression
Whats effects of allopogrelnanole?
is a metabolite progesterone
- calming (increases GABA), decreases anxiety, increases ability to handle stress
- neuroportective / neurogenesis (decreases neuroinflammation, brain fog, loss smell / memory / migraines / balance )
- improves sleep
- pain modulation
- anti depressive
what are some side effects of progestin only pill?
- breast tenderness
- spotting (thins endometrial, no break)
- incr. press, anxiety, depression
- dear. brain function, concentration, memory
- decr. sleep
- decr. pain modulation / tolerance
