OHSS introduction

Question 1

Pro-inflammatory mediators of OHSS

Answer 1

VEGF and others cytokines

Question 2

Epidemiology of OHSS

Answer 2

Occurrence of ovarian enlargement with
the local and systemic effects of proinflammatory mediators,including increased vascular permeability and
prothrombotic effect

Question 3

Physiology of OHSS

Answer 3

• Increased vascular permeability leads to loss of fluid into the third space, manifesting as ascites or, less
  commonly, pleural and pericardial effusions.
• Women with severe OHSS demonstrate hypovolaemia, with a typical loss of 20% of their calculated blood volume in the acute phase of OHSS.
• Accompanying this hypovolaemia is reduced serum osmolality and sodium

Question 4

% of OHSS

Answer 4

None, as cases of mild and moderate are not recorded and there is no agreed international classification