What is the ABCD of dementia?
A - affect on activities of daily living (ADLs)
B - behavioural and psychiatric symptoms
C - cognitive impairment
D - decline
What are the behavioural symptoms (B)?
Agitation
Altered circadian rhythm
Personality change
What are the psychiatric changes in dementia?
Anxiety
Depression
Psychosis
What are the 4 D’s of cognitive impairment in dementia?
Dysphasia
Dyspraxia
Dysgnosia
Dysexecutive function
What is dysphasia?
Loss of ability to express/understand
What is dysgnosia?
Loss of sense of “whereness”
What other part of cognition is impaired in dementia apart from dysphasia, dyspraxia, dysgnosia and dysexecutive function?
Memory
What is the course of alzheimers disease?
Symptoms –> diagnosis –> loss of ADL’s –> Behavioural decline –> moved to a home –> death
What are the main differences between alzheimers and delerium?
Alzheimers
Delerium
What is a typical difference between depression and delerium/dementia?
Depression presents with a lot of “don’t know” answers as apposed to the others where the patient tries to remember but can’t
Also associated with anxiety more than the other two
What are investigations for older people presenting with symptoms of dementia?
Collateral history most important
MMSE
MOCA
Addenbrookes clinical assessment (ACE)
Bloods
Specialist referral
What is the MOCA good for?
Delerium
What bloods should be tested?
B12
Thiamine
What imaging should be done?
MRI head - alzheimers
DATscan
What will be seen on MRI in alzheimers?
Marked temporal atrophy in early
General atrophy later
What does a DATscan test for?
Lewy body dementia
What does a DATscan show normally and in lewy body?
Normal - comma like uptake of dopamine
Lewy body - marked loss of dopamine uptake
What must never be forgotten in delerium?
SEPSIS
What score is used for sepsis?
SOFA score
Sequential organ failure score
Treatment of sepsis?
Sepsis 6
What is the SEPSIS 6?
All must occur within 1hr of presentation
Treatment of alzheimers?
Cholinesterase inhibitors
NMDA receptor antagonists
- Memantine
What psych drugs are helpful in alzheimers?
Antipsychotics
- Risperidone
Antidepressants
- SSRIs