Onc

Question 1

RAS [blk cap]

Answer 1

• bladder cancer
• lung ca.
• kidney ca.
• colon ca.
• pancreatic ca.

BLK CP (black cap)

Question 2

N-MYC

Answer 2

• Neuroblastoma
• Small Cell Lung Carcinoma

Question 3

ERB-B1

Answer 3

Squamous Cell Lung Carcinoma

Question 4

ERB-B2

Answer 4

Breast/Ovarian Cancer

Question 5

TGF-alpha

Answer 5

• Astrocytoma
• Hepatocellular carcinoma

Question 6

BCR-ABL

Answer 6

• CML

Question 7

BRCA-1 and BRCA-2

Answer 7

• Breast Cancer
• Ovarian Cancer

Question 8

NF-1

Answer 8

• Neurofibromatosis Type 1
• Neuroblastomas

Question 9

APC

Answer 9

• FAP (familial adenomatous polyposis coli)

Question 10

DCC

Answer 10

colon cancer

Question 11

P53

Answer 11

• Li-Fraumeni syndrome
• majority of cancers

Question 12

RB

Answer 12

• retinoblastoma

Question 13

WT-1

Answer 13

• Wilm’s Tumor

Question 14

Name the Oncology Med(s)
- decreases thymidine
(inhibits nucleotide synthesis)

Answer 14

• Methotrexate
• 5-FU

Question 15

Name the Oncology Med(s)
- decreases purine synthesis
(inhibits nucleotide synthesis)

Answer 15

6-Mercaptopurine
(inhibited by xanthine oxidase)

Question 16

Name the Oncology Med(s)
- inhibits DNA cross linkage

Answer 16

• alkylating agents
• cisplatin

Question 17

Name the Oncology Med(s)
- inhibits DNA intercalation
*can cause dilated cardiomyopathy

Answer 17

• dactinomycin
• doxorubicin

Question 18

Name the Oncology Med(s)
- causes DNA strand breakage & inhibits DNA intercalation

Answer 18

Bleomycin

Question 19

Name the Oncology Med(s)
- causes DNA strand breakage
(topoisomerase inhibitor)

Answer 19

Etoposide

Question 20

Name the Oncology Med(s)
- inhibit microtubule formation

Answer 20

• vincristine
• vinblastine

Question 21

Name the Oncology Med(s)
- inhibits microtubule disassembly

Answer 21

paclitaxel (taxanes)

Question 22

SMX inhibits ____ _____

Answer 22

dihydroproteroate synthetase

Question 23

TMP & Pyrimethamine & Methotrexate all inhibit ___ ____

Answer 23

dihydrofolate reductase

Question 24

Quinolones inhibit ___ ___

Answer 24

DNA gyrase
- inhibits nicking and closing during DNA replication

Question 25

Rifampin inhibits ___ ____ ____ ____

Answer 25

DNA dependent RNA polymerase

Question 26

t(15;17); Auer Rods

Answer 26

AML/APML

Question 27

t(9;22)

Answer 27

CML

Question 28

TRAP +

Answer 28

Hairy cell leukemia

Question 29

Smudge Cells (CD5)

Answer 29

CLL

Question 30

t(8:14)

Answer 30

Burkitt's Lymphoma (C-MYC activation)

Question 31

t(14:18)

Answer 31

Follicular Lymphoma (BCL-2 activation)

Question 32

t(11;14)

Answer 32

Mantle Cell Lymphoma

Question 33

t(11;22)

Answer 33

Ewing's Sarcoma

Question 34

Name this Lymphoma - CD 30 + - CD 15 + - EBV related

Answer 34

Hodgkin's Lymphoma - B-cell origin - Reed Sternberg cells - EBV "owl's eyes"

Question 35

Name this Neoplam - IL-6 + - HYPERcalcemia - Bence Jone Proteins in urine

Answer 35

Multiple Myeloma

Question 36

Name this Neoplasm - excessive IgM antibody (M Spike) - headaches/vision problems - pain and numbness of extremities

Answer 36

Waldenstrom Macroglobulinemia