ONC Miscellany

Question 1

cell cycle SPECIFIC agents

Answer 1

EXAMPLES: antimetabolites & microtubule inhibitors

• kill cancer cells during specific phases of the cell cycle

Question 2

cell cycle NON-SPECIFIC agents

Answer 2

EXAMPLES: alkylating agents & anthracyclines

• kill cancer cells in any phase of cell cycle

Question 3

“TARGETED” DRUGS

Answer 3

mAbs = monoclonal antibodies

TKIs = tyrosine kinase inhibitors

Question 4

DOSING

Answer 4

• flat or FIXED dosing
• based on patient weight = mg/kg
• based on body surface area = BSA
• DUBOIS or MOSTELLER
• USE ACTUAL BODY WEIGHT

Question 5

Phases of CELL CYCLE

Answer 5

M - mitosis - one cell becomes two cells

G0 - resting phase post mitosis - REST, NO ACTIVITY

G1 - post-mitotic phase - enzymes and proteins made

S phase - DNA synthesis & duplication

G2 - pre-mitotic phase - RNA and proteins GET READY TO DIVIDE

Question 6

Non-cell cycle specific agents

Answer 6

alkylating agents
anthracyclines
platinum agents

Question 7

CINV

Answer 7

chemotherapy-induced nausea and vomiting

Question 8

Secondary malignancy

Answer 8

• a new cancer that occurs as a result of previous treatment with radiation or chemotherapy
• may occur months or years after treatment and are a consequence or side effect of the initial cancer treatment

Question 9

HAND FOOT SYNDROME

Answer 9

PALMAR-PLANTAR ERYTHRODYESTHESIA

• mechanism unclear
• frequently occurs following treatment of 5-FU, capecitabine, cytarabine, liposomal doxorubicin
• cold compresses for temporary relief
• emollients for hands + feet
• corticosteroids/pain meds for inflammation + pain